Bioinformatic analysis of the potential effects on human health of herbicides for alternative use to glyphosate and atrazine

Authors

  • Tomas Lorusso Instituto de Biociencias, Biotecnología y Biología Traslacional (iB3), Departamento de Fisiología, Biología Molecular y Celular (DFBMC), Facultad de Ciencias Exactas y Naturales (FCEyN), Universidad de Buenos Aires (UBA), Buenos Aires, Argentina. Author https://orcid.org/0009-0002-1061-9117
  • Matías Blaustein Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Argentina. Author https://orcid.org/0000-0001-6309-6888
  • Mercedes García Carrillo Instituto de Biociencias, Biotecnología y Biología Traslacional (iB3), Departamento de Fisiología, Biología Molecular y Celular (DFBMC), Facultad de Ciencias Exactas y Naturales (FCEyN), Universidad de Buenos Aires (UBA), Buenos Aires, Argentina. Author https://orcid.org/0000-0001-7868-6047

DOI:

https://doi.org/10.56294/piii2024293

Abstract

In Argentina, since the mid-90s, an agricultural model based on genetically modified crops and herbicides such as glyphosate and atrazine has been adopted [1]. The resistance of weeds to these herbicides has led to the use of alternatives such as glufosinate ammonium, alachlor and mesotrione, whose effects on human health are poorly studied [2]. This raises concerns, especially for possible carcinogenic effects, which underlines the need for more research on these alternative herbicides [3]. 
The objective of this study was to evaluate the potential toxicological effect of these alternative herbicides, identifying the proteins that can interact with them directly or indirectly using the STITCH and STRING platforms [4, 5]. Then, those biological processes potentially affected as a consequence of the interaction of these herbicides with the identified proteins were identified. An enrichment analysis was performed on those overrepresented proteins/genes associated with the category “Biological Process” and “KEGG PATHWAYS” from the Gene Ontology and SHINYGO databases respectively [6].
It was found that, in general, these herbicides could affect both signaling pathways related to cell proliferation, programmed cell death, stress response, as well as the cellular response to xenobiotics, processing, maturation and biogenesis of ribosomal RNA. In addition, possible associated pathologies were found, such as neuro-degeneration, Lupus and cancer. These findings are consistent with previous reports on the toxic effects of these herbicides on human health, giving an account of their potential to produce diseases such as different types of cancer [7, 8, 9]

References

Cáceres, D. M., & Gras, C. (2020). A tipping point for agricultural expansion? Technological changes and capital accumulation in Argentina's rural sector. Journal of Agrarian Change, 20(1), 79-97.

Mesnage, R., & Antoniou, M. (2021). Mammalian toxicity of herbicides used in intensive GM crop farming. In Herbicides (pp. 143-180): Elsevier.

Leon, M. E., Schinasi, L. H., Lebailly, P., Beane Freeman, L. E., Nordby, K.-C., Ferro, G., . . . Baldi, I. (2019). Pesticide use and risk of non-Hodgkin lymphoid malignancies in agricultural cohorts from France, Norway and the USA: a pooled analysis from the AGRICOH consortium. International journal of epidemiology, 48(5), 1519-1535.

Szklarczyk, D., Santos, A., Von Mering, C., Jensen, L. J., Bork, P., & Kuhn, M. (2016). STITCH 5: augmenting protein–chemical interaction networks with tissue and affinity data. Nucleic acids research, 44(D1), D380-D384.

Szklarczyk, D., Gable, A. L., Lyon, D., Junge, A., Wyder, S., Huerta-Cepas, J., ... & Mering, C. V. (2019). STRING v11: protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets. Nucleic acids research, 47(D1), D607-D613.

Ge, S. X., Jung, D., & Yao, R. (2020). ShinyGO: a graphical gene-set enrichment tool for animals and plants. Bioinformatics, 36(8), 2628-2629.

Lajmanovich, R. C., Attademo, A. M., Lener, G., Boccioni, A. P. C., Peltzer, P. M., Martinuzzi, C. S., ... & Repetti, M. R. (2022). Glyphosate and glufosinate ammonium, herbicides commonly used on genetically modified crops, and their interaction with microplastics: Ecotoxicity in anuran tadpoles. Science of The Total Environment, 804, 150177.

Gangadhar, D., Babu, P. V., Pamanji, R., & Srikanth, K. (2021). The pursuit of alachlor herbicide toxicity on Eisenia fetida and its biochemical responses. Water, Air, & Soil Pollution, 232, 1-10.

Piancini, L. D. S., Guiloski, I. C., de Assis, H. S., & Cestari, M. M. (2015). Mesotrione herbicide promotes biochemical changes

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Published

2024-05-08

How to Cite

1.
Lorusso T, Blaustein M, García Carrillo M. Bioinformatic analysis of the potential effects on human health of herbicides for alternative use to glyphosate and atrazine. SCT Proceedings in Interdisciplinary Insights and Innovations [Internet]. 2024 May 8 [cited 2024 Oct. 7];2:293. Available from: https://proceedings.ageditor.ar/index.php/piii/article/view/262