Pharmacological and Non-pharmacological interventions for the prevention of Pre-eclampsia: a Systematic Review
DOI:
https://doi.org/10.56294/piii2023164Keywords:
treatment, prevention, preeclampsiaAbstract
Background: Hypertensive disorders during pregnancy are a major cause of severe illness, long-term disability, and maternal mortality. Preeclampsia is considered one of the main diseases associated with these disorders, and it is important to know how to facilitate its prevention through early detection to achieve adequate clinical management. In this context, it has been proven that knowledge of risk factors, the quality of follow-up of these patients, early diagnosis and appropriate clinical management have a significant impact on minimizing these data. Objective: To unify, analyze and identify the available evidence about the possible benefits and risks of the preventive therapies available for the treatment of preeclampsia, to define the current level of evidence of this therapy and the effects on the clinical results of maternal and child health. Material and Methods: Data collection was performed through a search in the online databases: SciELO (Scientific Electronic Library Online) and PUBMED. The articles were downloaded from the cited platforms, and Zotero program was used to make the proper citations and references. The research will be made up of published and updated literature that reflects the importance and types of preventive treatment in preeclampsia.
Results and discusión: Fifteen studies that met the criteria related to the object of study were included. According to the results achieved, the study allowed obtaining a more detailed view of the studies that emerged from the data search, highlighting categories such as those that reflect knowledge of non-pharmacological and pharmacological treatments and their real effectiveness for the prevention of preeclampsia. Conclusions: The analysis carried out shows that the findings of this study suggest that carrying out interventions for the prevention of preeclampsia in general is beneficial when the components that have a proven positive effect are mainly used. Abbreviations: (AIT) Alanine aminotransferase, (AST) Aspartate Aminotransferase, (UIL) Intrauterine growth restriction, (DIC) Disseminated intravascular coagulation, (PE) Preeclampsia
References
Churchill D, Duley L, Thornton JG, Jones L. Interventionist versus expectant care for severe pre-eclampsia between 24 and 34 weeks’ gestation. Cochrane Pregnancy and Childbirth Group, organizador. Cochrane Database of Systematic Reviews [Internet]. 26 de julho de 2013 [citado 6 de dezembro de 2022]; Disponível em: https://doi.wiley.com/10.1002/14651858.CD003106.pub2
Duffy J, Hirsch M, Kawsar A, Gale C, Pealing L, Plana M, et al. Outcome reporting across randomised controlled trials evaluating therapeutic interventions for pre-eclampsia. BJOG: Int J Obstet Gy. novembro de 2017;124(12):1829–39.
Sánchez SE. Actualizaci ón en la epidemiología de la preeclampsia. Rev peru ginecol obstet. 28 de janeiro de 2015;60(4):309–20.
Xu M, Guo D, Gu H, Zhang L, Lv S. Selenium and Preeclampsia: a Systematic Review and Meta-analysis. Biol Trace Elem Res. junho de 2016;171(2):283–92.
Ray A, Ray S. Epidural therapy for the treatment of severe pre-eclampsia in non labouring women. Cochrane Pregnancy and Childbirth Group, organizador. Cochrane Database of Systematic Reviews [Internet]. 28 de novembro de 2017 [citado 8 de dezembro de 2022];2017(11). Disponível em: http://doi.wiley.com/10.1002/14651858.CD009540.pub2
Wolf HT, Owe KM, Juhl M, Hegaard HK. Leisure Time Physical Activity and the Risk of Pre-eclampsia: A Systematic Review. Matern Child Health J. maio de 2014;18(4):899–910.
Bartsch E, Medcalf KE, Park AL, Ray JG. Clinical risk factors for pre-eclampsia determined in early pregnancy: systematic review and meta-analysis of large cohort studies. BMJ. 19 de abril de 2016;i1753.
Dodd JM, O’Brien C, Grivell RM. Preventing pre-eclampsia - are dietary factors the key? BMC Med. dezembro de 2014;12(1):176.
Wu P, van den Berg C, Alfirevic Z, O’Brien S, Röthlisberger M, Baker P, et al. Early Pregnancy Biomarkers in Pre-Eclampsia: A Systematic Review and Meta-Analysis. IJMS. 23 de setembro de 2015;16(9):23035–56.
Berhan Y, Berhan A. Should magnesium sulfate be administered to women with mild pre-eclampsia? A systematic review of published reports on eclampsia: Systematic review of reports on eclampsia. J Obstet Gynaecol Res. junho de 2015;41(6):831–42.
Kasawara KT, Nascimento SLD, Costa ML, Surita FG, E Silva JLP. Exercise and physical activity in the prevention of pre-eclampsia: systematic review: Physical activity in pre-eclampsia prevention. Acta Obstetricia et Gynecologica Scandinavica. outubro de 2012;91(10):1147–57.
Khaing W, Vallibhakara SAO, Tantrakul V, Vallibhakara O, Rattanasiri S, McEvoy M, et al. Calcium and Vitamin D Supplementation for Prevention of Preeclampsia: A Systematic Review and Network Meta-Analysis. Nutrients. 18 de outubro de 2017;9(10):1141.
Rahnemaei FA, Fashami MA, Abdi F, Abbasi M. Factors effective in the prevention of Preeclampsia:A systematic review. Taiwanese Journal of Obstetrics and Gynecology. março de 2020;59(2):173–82.
Bujold E, Roberge S, Lacasse Y, Bureau M, Audibert F, Marcoux S, et al. Prevention of Preeclampsia and Intrauterine Growth Restriction With Aspirin Started in Early Pregnancy: A Meta-Analysis. Obstetrics & Gynecology. agosto de 2010;116(2):402–14.
Vahedian-Azimi A, Karimi L, Reiner Ž, Makvandi S, Sahebkar A. Effects of statins on preeclampsia: A systematic review. Pregnancy Hypertension. março de 2021;23:123–30.
Downloads
Published
Issue
Section
License
Copyright (c) 2023 Marlen Vasconcelos Alves Melo, Marcelo Adrian Estrin (Author)
This work is licensed under a Creative Commons Attribution 4.0 International License.
The article is distributed under the Creative Commons Attribution 4.0 License. Unless otherwise stated, associated published material is distributed under the same licence.