The rol of bowel preparation in colorectal surgery
DOI:
https://doi.org/10.56294/piii2023167Keywords:
colorectal surgery, Surgical preparation, anastomotic leakage, bowel preparation, antibiotic prophylaxisAbstract
Background: Mechanical preparation of the colon has been an essential practice for colorectal surgery. During the 1930's it was popularized on the grounds that stool, due to its bacterial content, predisposed to surgical site infections and favored anastomotic dehiscence. To reduce the incidence of surgical site infections, the use of antibiotic prophylaxis associated with mechanical preparation has been recommended. After some years and experimental studies in animals, emergency surgeries without preparation and good results, its use was questioned, in fact, it was sought to avoid the discomfort and morbidity involved. With the advent of laparoscopic surgery, it was questioned again since it was believed that it was necessary to prepare the colon to be able to manipulate it, but later it was demonstrated that it was not necessary. The relevance of this paper is to illustrate the changes described in the last decades regarding colonic preparation and to update the reader on current recommendations. Despite the controversies over the years, the paradigm is continuously changing. Material and methods: A systematic review was carried out with a literature search in the following databases: Google Scholar, Cocharme Library, Espistemonikos and PubMed (MEDLINE). The MESH search terms used in the present study were colorectal surgery; Surgical preparation; anastomotic leakage; bowel preparation; antibiotic prophylaxis. The Boolean operators OR and AND were used. By selecting potential papers and important information to identify the best outcome in patients undergoing elective colorectal surgery, a total of 363 articles were identified, of which a total of 30 were potential articles for this review. Results. Nine articles were selected after application of the inclusion and exclusion criteria. A total of 14,015 patients were studied, 54.60% were men and 45.40% were women. The patients were divided into different groups, those who received only mechanical preparation of the colon, those who received mechanical preparation combined with oral antibiotics, those who received only oral prophylaxis and those who did not receive prophylaxis. Of the total number of studies analyzed, a clear reduction in complications was observed in the patients who received combined treatment. Conclusion: The combination of mechanical colon preparation and oral antibiotics would be associated with a lower incidence of surgical site infections and anastomotic leakage compared to no mechanical preparation
References
Lee JH, Ahn BK, Ryu J, Lee KH. Mechanical bowel preparation combined with oral antibiotics in colorectal cancer surgery: a nationwide population-based study. Int J Colorectal Dis. septiembre de 2021;36(9):1929-35.
Agnes A, Puccioni C, D’Ugo D, Gasbarrini A, Biondi A, Persiani R. The gut microbiota and colorectal surgery outcomes: facts or hype? A narrative review. BMC Surg. 12 de febrero de 2021;21(1):83.
Roig JV, García-Armengol J, Alós R, Solana A, Rodríguez-Carrillo R, Galindo P, et al. Preparar el colon para la cirugía. ¿Necesidad real o nada más (y nada menos) que el peso de la tradición? Cir Esp. mayo de 2007;81(5):240-6.
Leenen JPL, Hentzen JEKR, Ockhuijsen HDL. Effectiveness of mechanical bowel preparation versus no preparation on anastomotic leakage in colorectal surgery: a systematic review and meta-analysis. Updat Surg. junio de 2019;71(2):227-36.
Zhao Y, Li B, Sun Y, Liu Q, Cao Q, Li T, et al. Risk Factors and Preventive Measures for Anastomotic Leak in Colorectal Cancer. Technol Cancer Res Treat. enero de 2022;21:153303382211189.
Pellino G, Solís‐Peña A, Kraft M, Huguet BM, Espín‐Basany E. Preoperative oral antibiotics with versus without mechanical bowel preparation to reduce surgical site infections following colonic resection: Protocol for an international randomized controlled trial (ORALEV2). Colorectal Dis. agosto de 2021;23(8):2173-81.
Hequera JA, Obregón JG, Cabas J, Díaz C. Preparación Mecánica del Colon para la Cirugía. ¿Es Necesaria? 2013;24.
Mulder T, Kluytmans JAJW. Oral antibiotics prior to colorectal surgery: Do they have to be combined with mechanical bowel preparation? Infect Control Hosp Epidemiol. agosto de 2019;40(8):922-7.
Toh JWT, Phan K, Hitos K, Pathma-Nathan N, El-Khoury T, Richardson AJ, et al. Association of Mechanical Bowel Preparation and Oral Antibiotics Before Elective Colorectal Surgery With Surgical Site Infection: A Network Meta-analysis. JAMA Netw Open. 12 de octubre de 2018;1(6):e183226.
Futier E, Jaber S, Garot M, Vignaud M, Panis Y, Slim K, et al. Effect of oral antimicrobial prophylaxis on surgical site infection after elective colorectal surgery: multicentre, randomised, double blind, placebo controlled trial. BMJ. 3 de noviembre de 2022;e071476.
Papp G, Saftics G, Szabó BE, Baracs J, Vereczkei A, Kollár D, et al. Systemic versus Oral and Systemic Antibiotic Prophylaxis (SOAP) study in colorectal surgery: prospective randomized multicentre trial. Br J Surg. 5 de abril de 2021;108(3):271-6.
Scarborough JE, Mantyh CR, Sun Z, Migaly J. Combined Mechanical and Oral Antibiotic Bowel Preparation Reduces Incisional Surgical Site Infection and Anastomotic Leak Rates After Elective Colorectal Resection: An Analysis of Colectomy-Targeted ACS NSQIP. Ann Surg. agosto de 2015;262(2):331-7.
Willis MA, Toews I, Soltau SL, Kalff JC, Meerpohl JJ, Vilz TO. Preoperative combined mechanical and oral antibiotic bowel preparation for preventing complications in elective colorectal surgery. Cochrane Colorectal Group, editor. Cochrane Database Syst Rev [Internet]. 7 de febrero de 2023 [citado 7 de mayo de 2023];2023(2). Disponible en: http://doi.wiley.com/10.1002/14651858.CD014909.pub2
Zhang LM, Schuitevoerder D, White MG, Feldt S, Krishnan P, Hyman N, et al. Combined mechanical and oral antibiotic bowel preparation is associated with prolonged recurrence‐free survival following surgery for colorectal cancer. J Surg Oncol. diciembre de 2021;124(7):1106-14.
Barrera E A, Cid B H, Bannura C G, Contreras R J, Zúñiga T C, Mansilla E J. Utilidad de la preparación mecánica anterógrada en cirugía colorrectal electiva. Resultados de una serie prospectiva y aleatoria. Rev Chil Cir. agosto de 2012;64(4):373-7.
Vo E, Massarweh NN, Chai CY, Tran Cao HS, Zamani N, Abraham S, et al. Association of the Addition of Oral Antibiotics to Mechanical Bowel Preparation for Left Colon and Rectal Cancer Resections With Reduction of Surgical Site Infections. JAMA Surg. 1 de febrero de 2018;153(2):114.
Vadhwana B, Pouzi A, Surjus Kaneta G, Reid V, Claxton D, Pyne L, et al. Preoperative oral antibiotic bowel preparation in elective resectional colorectal surgery reduces rates of surgical site infections: a single-centre experience with a cost-effectiveness analysis. Ann R Coll Surg Engl. febrero de 2020;102(2):133-40.
Ambe PC, Zarras K, Stodolski M, Wirjawan I, Zirngibl H. Routine preoperative mechanical bowel preparation with additive oral antibiotics is associated with a reduced risk of anastomotic leakage in patients undergoing elective oncologic resection for colorectal cancer. World J Surg Oncol. diciembre de 2019;17(1):20.
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